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How does TDP-43 seeding lead to cytoplasmic aggregation and nuclear loss of function?

TDP-43 seeding cytoplasmic aggregation mechanism
TDP-43 nuclear loss of function
TDP-43 proteinopathy pathogenesis
TDP-43 aggregation in neurodegenerative diseases
TDP-43 cytoplasmic mislocalization
TDP-43 seeding and neurodegeneration

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